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p ripk1  (Proteintech)


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    Proteintech p ripk1
    THM induced PANoptosis by assembling PANoptosome. A Immunoblot analysis was used to detect the activation markers of pyroptosis (GSDME, AIM2), apoptosis (PARP, Cleaved-CASP3, Cleaved-CASP8) and necroptosis <t>(p-RIPK1,</t> p-RIPK3, p-MLKL) in the cell lysates of HT29, HCT116, A549 and H1299 cells after treatment with THM. β-actin was used as a loading control. B Representative images of IHC staining for Ki67, Cleaved-PARP, Cleaved-CASP3, AIM2, p-MLKL and p-RIPK1 in tumor tissues, scale bar = 50 μm. C-D HCT116 (75 µM) and A549 (90 µM) cells were treated with THM for 24 h, then immunofluorescence confocal laser microscopy analysis was performed after staining with the specified PANoptosome complex antibodies. Representative images illustrated the pairwise co-localization of ASC with CASP8, RIPK3, and AIM2 respectively. Scale bar = 20 μm
    P Ripk1, supplied by Proteintech, used in various techniques. Bioz Stars score: 93/100, based on 18 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/p ripk1/product/Proteintech
    Average 93 stars, based on 18 article reviews
    p ripk1 - by Bioz Stars, 2026-02
    93/100 stars

    Images

    1) Product Images from "Tetrahydromagnolol targets TRIM38 to mediate PANoptosis in cancer cells and has the potential for synergistic cancer therapy"

    Article Title: Tetrahydromagnolol targets TRIM38 to mediate PANoptosis in cancer cells and has the potential for synergistic cancer therapy

    Journal: Experimental Hematology & Oncology

    doi: 10.1186/s40164-025-00734-4

    THM induced PANoptosis by assembling PANoptosome. A Immunoblot analysis was used to detect the activation markers of pyroptosis (GSDME, AIM2), apoptosis (PARP, Cleaved-CASP3, Cleaved-CASP8) and necroptosis (p-RIPK1, p-RIPK3, p-MLKL) in the cell lysates of HT29, HCT116, A549 and H1299 cells after treatment with THM. β-actin was used as a loading control. B Representative images of IHC staining for Ki67, Cleaved-PARP, Cleaved-CASP3, AIM2, p-MLKL and p-RIPK1 in tumor tissues, scale bar = 50 μm. C-D HCT116 (75 µM) and A549 (90 µM) cells were treated with THM for 24 h, then immunofluorescence confocal laser microscopy analysis was performed after staining with the specified PANoptosome complex antibodies. Representative images illustrated the pairwise co-localization of ASC with CASP8, RIPK3, and AIM2 respectively. Scale bar = 20 μm
    Figure Legend Snippet: THM induced PANoptosis by assembling PANoptosome. A Immunoblot analysis was used to detect the activation markers of pyroptosis (GSDME, AIM2), apoptosis (PARP, Cleaved-CASP3, Cleaved-CASP8) and necroptosis (p-RIPK1, p-RIPK3, p-MLKL) in the cell lysates of HT29, HCT116, A549 and H1299 cells after treatment with THM. β-actin was used as a loading control. B Representative images of IHC staining for Ki67, Cleaved-PARP, Cleaved-CASP3, AIM2, p-MLKL and p-RIPK1 in tumor tissues, scale bar = 50 μm. C-D HCT116 (75 µM) and A549 (90 µM) cells were treated with THM for 24 h, then immunofluorescence confocal laser microscopy analysis was performed after staining with the specified PANoptosome complex antibodies. Representative images illustrated the pairwise co-localization of ASC with CASP8, RIPK3, and AIM2 respectively. Scale bar = 20 μm

    Techniques Used: Western Blot, Activation Assay, Control, Immunohistochemistry, Immunofluorescence, Microscopy, Staining



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    THM induced PANoptosis by assembling PANoptosome. A Immunoblot analysis was used to detect the activation markers of pyroptosis (GSDME, AIM2), apoptosis (PARP, Cleaved-CASP3, Cleaved-CASP8) and necroptosis <t>(p-RIPK1,</t> p-RIPK3, p-MLKL) in the cell lysates of HT29, HCT116, A549 and H1299 cells after treatment with THM. β-actin was used as a loading control. B Representative images of IHC staining for Ki67, Cleaved-PARP, Cleaved-CASP3, AIM2, p-MLKL and p-RIPK1 in tumor tissues, scale bar = 50 μm. C-D HCT116 (75 µM) and A549 (90 µM) cells were treated with THM for 24 h, then immunofluorescence confocal laser microscopy analysis was performed after staining with the specified PANoptosome complex antibodies. Representative images illustrated the pairwise co-localization of ASC with CASP8, RIPK3, and AIM2 respectively. Scale bar = 20 μm
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    THM induced PANoptosis by assembling PANoptosome. A Immunoblot analysis was used to detect the activation markers of pyroptosis (GSDME, AIM2), apoptosis (PARP, Cleaved-CASP3, Cleaved-CASP8) and necroptosis <t>(p-RIPK1,</t> p-RIPK3, p-MLKL) in the cell lysates of HT29, HCT116, A549 and H1299 cells after treatment with THM. β-actin was used as a loading control. B Representative images of IHC staining for Ki67, Cleaved-PARP, Cleaved-CASP3, AIM2, p-MLKL and p-RIPK1 in tumor tissues, scale bar = 50 μm. C-D HCT116 (75 µM) and A549 (90 µM) cells were treated with THM for 24 h, then immunofluorescence confocal laser microscopy analysis was performed after staining with the specified PANoptosome complex antibodies. Representative images illustrated the pairwise co-localization of ASC with CASP8, RIPK3, and AIM2 respectively. Scale bar = 20 μm
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    p ripk1 antibody  (Proteintech)
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    THM induced PANoptosis by assembling PANoptosome. A Immunoblot analysis was used to detect the activation markers of pyroptosis (GSDME, AIM2), apoptosis (PARP, Cleaved-CASP3, Cleaved-CASP8) and necroptosis <t>(p-RIPK1,</t> p-RIPK3, p-MLKL) in the cell lysates of HT29, HCT116, A549 and H1299 cells after treatment with THM. β-actin was used as a loading control. B Representative images of IHC staining for Ki67, Cleaved-PARP, Cleaved-CASP3, AIM2, p-MLKL and p-RIPK1 in tumor tissues, scale bar = 50 μm. C-D HCT116 (75 µM) and A549 (90 µM) cells were treated with THM for 24 h, then immunofluorescence confocal laser microscopy analysis was performed after staining with the specified PANoptosome complex antibodies. Representative images illustrated the pairwise co-localization of ASC with CASP8, RIPK3, and AIM2 respectively. Scale bar = 20 μm
    P Ripk1 Antibody, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/p ripk1 antibody/product/Proteintech
    Average 96 stars, based on 1 article reviews
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    Image Search Results


    THM induced PANoptosis by assembling PANoptosome. A Immunoblot analysis was used to detect the activation markers of pyroptosis (GSDME, AIM2), apoptosis (PARP, Cleaved-CASP3, Cleaved-CASP8) and necroptosis (p-RIPK1, p-RIPK3, p-MLKL) in the cell lysates of HT29, HCT116, A549 and H1299 cells after treatment with THM. β-actin was used as a loading control. B Representative images of IHC staining for Ki67, Cleaved-PARP, Cleaved-CASP3, AIM2, p-MLKL and p-RIPK1 in tumor tissues, scale bar = 50 μm. C-D HCT116 (75 µM) and A549 (90 µM) cells were treated with THM for 24 h, then immunofluorescence confocal laser microscopy analysis was performed after staining with the specified PANoptosome complex antibodies. Representative images illustrated the pairwise co-localization of ASC with CASP8, RIPK3, and AIM2 respectively. Scale bar = 20 μm

    Journal: Experimental Hematology & Oncology

    Article Title: Tetrahydromagnolol targets TRIM38 to mediate PANoptosis in cancer cells and has the potential for synergistic cancer therapy

    doi: 10.1186/s40164-025-00734-4

    Figure Lengend Snippet: THM induced PANoptosis by assembling PANoptosome. A Immunoblot analysis was used to detect the activation markers of pyroptosis (GSDME, AIM2), apoptosis (PARP, Cleaved-CASP3, Cleaved-CASP8) and necroptosis (p-RIPK1, p-RIPK3, p-MLKL) in the cell lysates of HT29, HCT116, A549 and H1299 cells after treatment with THM. β-actin was used as a loading control. B Representative images of IHC staining for Ki67, Cleaved-PARP, Cleaved-CASP3, AIM2, p-MLKL and p-RIPK1 in tumor tissues, scale bar = 50 μm. C-D HCT116 (75 µM) and A549 (90 µM) cells were treated with THM for 24 h, then immunofluorescence confocal laser microscopy analysis was performed after staining with the specified PANoptosome complex antibodies. Representative images illustrated the pairwise co-localization of ASC with CASP8, RIPK3, and AIM2 respectively. Scale bar = 20 μm

    Article Snippet: Primary antibodies were incubated with slides overnight at 4 °C, including Ki67 (CST, 9449, 1:1500), Cleaved-PARP (CST, 5625, 1:50), Cleaved-CASP3 (CST, 9664, 1:2000), AIM2 (Proteintech, 20590-1-AP, 1:100), p-MLKL (UpingBio, YP-Ab-10353, 1:200), p-RIPK1 (Proteintech, 28252-1-AP, 1:100) and TRIM38 (Proteintech, 13405-1-AP, 1:100).

    Techniques: Western Blot, Activation Assay, Control, Immunohistochemistry, Immunofluorescence, Microscopy, Staining